Effect of a composite Indian herbal preparation, CIHP(III) on avoidance learning during endurance performance of rats.

A nine week cross over study (5 weeks drug administration and 4 weeks withdrawal) was performed to see the effect of a composite Indian herbal preparation (CIHP III), viz. Mentat, on avoidance learning during endurance performance of albino rats. Runimex, a circular runway was used for this purpose. The number of stimuli viz. electrical shock of 10 mv, in drug treated rats at an oral dose of 47.86 mg/100 g body wt/single dose/day for 5 days were significantly reduced as compared to rats not taking any drug. The number of stimuli decreased significantly when the drug was started in the control group. No change in avoidance learning was observed over the period of 9 weeks in another group of rats. Results indicate significant improvement in avoidance learning during endurance performance due to the intake of CIHP(III).